| Language | US English |
| Inclusion criteria | < 80% on PNT; able to name at least 5 out of 40 items during fMRI; WAB-R spontaneous speech ≥ 2; WAB-R auditory comprehension ≥ 2 |
| Number of individuals with aphasia | 87 |
| Number of control participants | 0 |
| Were any of the participants included in any previous studies? | Yes (65 were previously included in Fridriksson et al. (2018), a tDCS study) |
| Is age reported for patients and controls, and matched? | Yes (typical BDNF genotype group mean 59.6 ± 11.2 years, range 29-77 years; atypical BDNF genotype group mean 57.7 ± 10.9 years, range 30-76 years) |
| Is sex reported for patients and controls, and matched? | Yes (males: 58; females: 29) |
| Is handedness reported for patients and controls, and matched? | Yes (right: 87; left: 0) |
| Is time post stroke onset reported and appropriate to the study design? | Yes (typical BDNF genotype group: mean 44.0 ± 38.7 months; atypical BDNF genotype group: mean 34.5 ± 36.9 months; all participants > 6 months) |
| To what extent is the nature of aphasia characterized? | Severity and type |
| Language evaluation | WAB, PNT, PPT |
| Aphasia severity | Typical BDNF genotype group: AQ mean 64.2 ± 20.3; atypical BDNF genotype group: AQ mean 54.3 ± 21.0 |
| Aphasia type | Typical BDNF genotype group: 25 Broca's, 12 anomic, 11 conduction, 2 transcortical motor aphasia, 2 Wernicke's, 1 global; atypical BDNF genotype group: 16 Broca's, 6 anomic, 6 conduction, 3 global, 3 Wernicke's |
| First stroke only? | No |
| Stroke type | Mixed etiologies |
| To what extent is the lesion distribution characterized? | Lesion overlay |
| Lesion extent | Typical BDNF genotype group: 121.4 ± 73.2 cc; atypical BDNF genotype group: 142.2 ± 88.4 cc |
| Lesion location | L MCA |
| Participants notes | — |
| Modality | fMRI |
| Is the study cross-sectional or longitudinal? | Cross-sectional |
| If longitudinal, at what time point(s) were imaging data acquired? | — |
| If longitudinal, was there any intervention between the time points? | — |
| Is the scanner described? | Yes (Siemens Trio 3 Tesla or Siemens Prisma 3 Tesla) |
| Is the timing of stimulus presentation and image acquisition clearly described and appropriate? | Yes |
| Design type | Event-related |
| Total images acquired | 60 |
| Are the imaging acquisition parameters, including coverage, adequately described and appropriate? | Yes (whole brain) |
| Is preprocessing and intrasubject coregistration adequately described and appropriate? | Yes |
| Is first level model fitting adequately described and appropriate? | Yes |
| Is intersubject normalization adequately described and appropriate? | Yes |
| Imaging notes | sparse sampling |
| Language condition | Picture naming |
| Control condition | Viewing abstract pictures |
| Are the conditions matched for visual demands? | Yes |
| Are the conditions matched for auditory demands? | No |
| Are the conditions matched for motor demands? | No |
| Are the conditions matched for cognitive/executive demands? | No |
| Is accuracy matched between the language and control tasks for all relevant groups? | N/A, tasks not comparable |
| Is reaction time matched between the language and control tasks for all relevant groups? | N/A, tasks not comparable |
| Behavioral data notes | — |
| Are control data reported in this paper or another that is referenced? | No |
| Does the contrast selectively activate plausible relevant language regions in the control group? | Unknown |
| Are activations lateralized in the control data? | Unknown |
| Control activation notes | — |
| Contrast notes | — |
| First level contrast | Picture naming vs viewing abstract pictures |
| Analysis class | Cross-sectional between two groups with aphasia |
| Group(s) | Aphasia with typical genotype (n = 53) vs atypical genotype (n = 34) |
| Covariate | — |
| Is the second level contrast valid in terms of the group(s), time point(s), and measures involved? | Yes |
| Is accuracy matched across the second level contrast? | Yes, matched |
| Is reaction time matched across the second level contrast? | Unknown, not reported |
| Behavioral data notes | — |
| Type of analysis | Voxelwise |
| Search volume | |
| Correction for multiple comparisons | Voxelwise FWE correction |
| Software | SPM12 |
| Voxelwise p | — |
| Cluster extent | — |
| Statistical details | — |
| Findings | None |
| Findings notes | — |
