| Language | US English |
| Inclusion criteria | Agrammatic |
| Number of individuals with aphasia | 6 |
| Number of control participants | 12 |
| Were any of the participants included in any previous studies? | No |
| Is age reported for patients and controls, and matched? | Yes (mean 54 years, range 38-66 years) |
| Is sex reported for patients and controls, and matched? | Yes (males: 5; females: 1) |
| Is handedness reported for patients and controls, and matched? | Yes (right: 6; left: 0) |
| Is time post stroke onset reported and appropriate to the study design? | Yes (range 6-146 months) |
| To what extent is the nature of aphasia characterized? | Comprehensive battery |
| Language evaluation | WAB, NAVS, narrative language sample |
| Aphasia severity | AQ range 66.8-85.0 |
| Aphasia type | All agrammatic; per WAB scores provided: 3 Broca's, 3 unclassified |
| First stroke only? | Yes |
| Stroke type | Not stated |
| To what extent is the lesion distribution characterized? | Individual lesions |
| Lesion extent | Not stated |
| Lesion location | 5 L MCA, 1 R MCA with aphasia |
| Participants notes | — |
| Modality | fMRI |
| Is the study cross-sectional or longitudinal? | Longitudinal—chronic treatment |
| If longitudinal, at what time point(s) were imaging data acquired? | T1: pre-treatment/chronic; T2: post-treatment, 9-15 weeks later |
| If longitudinal, was there any intervention between the time points? | Treatment of underlying forms |
| Is the scanner described? | Yes (Siemens Trio 3 Tesla) |
| Is the timing of stimulus presentation and image acquisition clearly described and appropriate? | No (total images acquired not stated) |
| Design type | Event-related |
| Total images acquired | not stated |
| Are the imaging acquisition parameters, including coverage, adequately described and appropriate? | Yes (whole brain) |
| Is preprocessing and intrasubject coregistration adequately described and appropriate? | Yes |
| Is first level model fitting adequately described and appropriate? | Yes |
| Is intersubject normalization adequately described and appropriate? | Yes |
| Imaging notes | — |
| Language condition | Auditory sentence-picture matching (all three sentence types) |
| Control condition | Rest |
| Are the conditions matched for visual demands? | No |
| Are the conditions matched for auditory demands? | No |
| Are the conditions matched for motor demands? | No |
| Are the conditions matched for cognitive/executive demands? | No |
| Is accuracy matched between the language and control tasks for all relevant groups? | N/A, tasks not comparable |
| Is reaction time matched between the language and control tasks for all relevant groups? | N/A, tasks not comparable |
| Behavioral data notes | — |
| Are control data reported in this paper or another that is referenced? | No |
| Does the contrast selectively activate plausible relevant language regions in the control group? | Unknown |
| Are activations lateralized in the control data? | Unknown |
| Control activation notes | — |
| Contrast notes | — |
| First level contrast | Auditory sentence-picture matching (all three sentence types) vs rest |
| Analysis class | Longitudinal change in aphasia |
| Group(s) | Aphasia T2 vs T1 |
| Covariate | — |
| Is the second level contrast valid in terms of the group(s), time point(s), and measures involved? | Yes |
| Is accuracy matched across the second level contrast? | Appear similar |
| Is reaction time matched across the second level contrast? | Appear similar |
| Behavioral data notes | — |
| Type of analysis | Regions of interest (ROI) |
| ROI type | Anatomical |
| How many ROIs are there? | 18 |
| What are the ROI(s)? | (1) L BA 7; (2) L BA 9; (3) L BA 13; (4) L BA 21; (5) L BA 22; (6) L BA 39; (7) L BA 40; (8) L BA 44; (9) L BA 45; (10-18) homotopic counterparts |
| How are the ROI(s) defined? | WFU pickatlas; proportion of patients who showed increases and decreases in (parts of) each ROI in individual fixed effects SPM analyses |
| Correction for multiple comparisons | No correction |
| Statistical details | — |
| Findings | ↑ L angular gyrus
↑ L superior parietal
↑ L mid temporal
↑ R supramarginal gyrus
↑ R superior parietal
↓ L insula
↓ L posterior STG |
| Findings notes | These are the regions involved in what the authors interpret as a "general shift" |
